In a large bowl, combine the ground beef, bread crumbs, milk, brown sugar, ketchup, egg, chopped onion, garlic powder, oregano, salt, and pepper. Mix until just combined.

Shape and Cook:

Form the mixture into a loaf shape and place it in the crockpot.

Cover and cook on low for 6-7 hours or on high for 3-4 hours, until the meatloaf reaches an internal temperature of 160°F (71°C).

Serve:

Let the meatloaf rest for 10 minutes before slicing. Serve with your favorite sides.

Prep Time: 15 minutes | Cooking Time: 6-7 hours (low) or 3-4 hours (high) | Total Time: 6.5-7.5 hours (low) or 3.5-4.5 hours (high)

K cal: 350 k cal per serving | Servings: 6 servings.